ISDS was founded by a group of academics based at the University of the Philippines, Diliman in April 1991 as an independent policy research training and advocacy institution. It was established in response to the need for a continuing evaluation and interpretation of changes in national and global affairs for serious international, regional and national audiences. It is also a response to the need to provide academics a venue for research to enrich teaching and to provide inputs to policy making. It is also the institutional vehicle for regional networks in which its founding members had been involved, particularly the ASEAN Institutes of Strategic and International Studies (ASEAN ISIS).
It was registered with the Securities and Exchange Commission as an independent, non-stock, non-profit professional research and training organization in January 1992.

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